Synthesis and antitumour activity of new tiazofurin analogues bearing a 2,3-anhydro functionality in the furanose ring

Mirjana Popsavin; Sasa Spaić; Milos Svircev; Vesna Kojić; Gordana Bogdanović; Velimir Popsavin

doi:10.1016/j.bmcl.2007.05.050

Synthesis and antitumour activity of new tiazofurin analogues bearing a 2,3-anhydro functionality in the furanose ring

Bioorg Med Chem Lett. 2007 Aug 1;17(15):4123-7. doi: 10.1016/j.bmcl.2007.05.050. Epub 2007 May 23.

Authors

Mirjana Popsavin¹, Sasa Spaić, Milos Svircev, Vesna Kojić, Gordana Bogdanović, Velimir Popsavin

Affiliation

¹ Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia. mpopsavin@ih.ns.ac.yu

PMID: 17543526
DOI: 10.1016/j.bmcl.2007.05.050

Abstract

This paper describes a divergent de novo synthesis of 2-(2,3-anhydro-beta-dribofuranosyl)thiazole-4-carboxamide (2',3'-anhydro-tiazofurin) and the corresponding alpha- and beta-homo-C-nucleosides, as well as evaluation of their antitumour activities in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Furans / chemistry
IMP Dehydrogenase / antagonists & inhibitors
Ribavirin / analogs & derivatives*
Ribavirin / chemical synthesis
Ribavirin / chemistry
Ribavirin / pharmacology

Substances

Antineoplastic Agents
Furans
Ribavirin
IMP Dehydrogenase
tiazofurin