Computed radiography (CR) has been shown to have relatively low sensitivity for detection of pulmonary nodules. This poor sensitivity precludes its use as a screening modality despite the low cost, low dose and wide distribution of devices. The purpose of this study was to apply multi-objective frequency processing (MFP) to CR images and to evaluate its usefulness for diagnosing subtle lung abnormalities. Fifty CR images with simulated subtle lung abnormalities were obtained from 50 volunteers. Each image was processed with MFP. We cut chest images. The chest image was divided into two rights and left. A total of 200 half-chest images (100 MFP-processed images and 100 MFP-unprocessed images) were prepared. Five radiologists participated in this study. ROC analyses demonstrated that the detection rate of simulated subtle lung abnormalities on the CR images was significantly better with MFP (Az=0.8508) than without MFP (Az=0.7925). The CR images processed with MFP could be useful for diagnosing subtle lung abnormalities. In conclusion, MFP appears to be useful for increasing the sensitivity and specificity in the detection of pulmonary nodules, ground-glass opacity (GGO) and reticular shadow.