Abstract
Bioactivity-guided fractionation of Saururus chinensis (Saururaceae) using a lymphoproliferation assay led us to isolate 5 lignans (compounds 1 - 5). Compounds 1 - 5 were identified as sauchinone, (-)-saucerneol, saucerneol C, manassantin A, and manassantin B, respectively, by spectroscopic analyses. The immunosuppressive activities of the active compounds were evaluated using lymphoproliferation, mixed leukocyte response, and Th1/Th2 cytokine assays. The relative potency was in the order: manassantin A, B > (-)-saucerneol > saucerneol C > sauchinone.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Proliferation / drug effects
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Cytokines / metabolism
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Humans
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / pharmacology*
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Immunosuppressive Agents / therapeutic use
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Lignans / administration & dosage
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Lignans / pharmacology
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Lignans / therapeutic use
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Lymphocyte Culture Test, Mixed
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Lymphocytes / drug effects*
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Lymphocytes / metabolism*
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Saururaceae*
Substances
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Cytokines
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Immunosuppressive Agents
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Lignans
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Plant Extracts