The present study investigates cultural differences in the effects of infertility on emotional distress. The study compares emotional distress among infertile people in three samples: Turkish migrants (n = 58), Turkish people living in Western Turkey (n = 46), and Dutch people (n = 199). Participants answered structured questionnaires on self-image, blame-guilt, sexual problems, depression, anxiety, and anger-hostility. Separate analyses were conducted for men and women. In general, the levels of emotional distress were higher for infertile Turkish migrant women and infertile Turkish women than they were for infertile Dutch women. Turkish migrant women reported more self-image problems and fewer feelings of blame-guilt than did Turkish women. Among men, Turkish migrant men showed the highest overall levels of emotional distress, and Dutch men showed the lowest. Our results indicate that the experience of infertility among Turkish migrants is more similar to those of Turkish people than it is to that of Dutch people, especially among women. The importance of having children in the different cultures may offer a possible explanation for these findings.