DNA microarray analysis of transcriptional responses of yeast cells to expression of core protein of hepatitis C virus

J Toxicol Sci. 2007 May;32(2):201-4. doi: 10.2131/jts.32.201.

Abstract

We monitored transcriptional changes in yeast cells in response to induced expression of the core protein of hepatitis C virus (HCV) using a DNA microarray. Expression of 16 genes involved in the unfolded-protein response was enhanced by inducing expression of the core protein in yeast cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Expression Regulation, Viral*
  • Hepacivirus / genetics
  • Hepacivirus / metabolism*
  • Oligonucleotide Array Sequence Analysis / methods*
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Transcription, Genetic*
  • Viral Core Proteins / chemistry
  • Viral Core Proteins / metabolism*

Substances

  • Saccharomyces cerevisiae Proteins
  • Viral Core Proteins
  • nucleocapsid protein, Hepatitis C virus