Abstract
In the cobalt focus experimental epilepsy model, severe hippocampal neuron damage occurs with marked EEG changes. The effects of TJ-960, a herbal medicine formulation, were studied on neuron damage in the CA1 area of rat hippocampus. Continuous oral administration of TJ-960 from one month prior to the cobalt application showed almost complete protection against hippocampal neuron damage induced by cobalt application to the cerebral cortex. TJ-960 also completely inhibited the EEG changes as well as the brain edema induced by cobalt application.
MeSH terms
-
Animals
-
Anticonvulsants / therapeutic use*
-
Body Water / metabolism
-
Brain Chemistry / drug effects
-
Brain Edema / chemically induced
-
Brain Edema / physiopathology
-
Brain Edema / prevention & control
-
Cerebral Cortex / drug effects*
-
Cerebral Cortex / metabolism
-
Cobalt
-
Drugs, Chinese Herbal / therapeutic use*
-
Electroencephalography
-
Epilepsy / chemically induced
-
Epilepsy / physiopathology
-
Epilepsy / prevention & control*
-
Hippocampus / drug effects*
-
Hippocampus / metabolism
-
Neurons / drug effects*
-
Pyramidal Tracts / drug effects
-
Rats
-
Rats, Inbred Strains
Substances
-
Anticonvulsants
-
Drugs, Chinese Herbal
-
shosaikoto-go-keishika-shakuyakuto
-
Cobalt