A systematic study of carboxylic acids in negative ion mode electrospray ionisation mass spectrometry providing a structural model for ion suppression

Mike N Clifford; Violeta Lopez; Laure Poquet; Gary Williamson; Nikolai Kuhnert

doi:10.1002/rcm.3038

A systematic study of carboxylic acids in negative ion mode electrospray ionisation mass spectrometry providing a structural model for ion suppression

Rapid Commun Mass Spectrom. 2007;21(13):2014-8. doi: 10.1002/rcm.3038.

Authors

Mike N Clifford¹, Violeta Lopez, Laure Poquet, Gary Williamson, Nikolai Kuhnert

Affiliation

¹ School of Biomedical and Molecular Sciences, The University of Surrey, Guildford, Surrey GU2 7XH, UK.

PMID: 17534854
DOI: 10.1002/rcm.3038

Abstract

We report a systematic investigation of the effects and structural requirements for ion suppression in negative ion mode electrospray ionisation mass spectrometry of a series of carboxylic acids and present a structural model rationalising ion suppression effects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetic Acid / chemistry
Carboxylic Acids / analysis*
Carboxylic Acids / chemistry
Ions*
Methanol / chemistry
Molecular Structure
Solutions / chemistry
Spectrometry, Mass, Electrospray Ionization / methods*
Water / chemistry

Substances

Carboxylic Acids
Ions
Solutions
Water
Acetic Acid
Methanol