Two new dialkoxycarbonylated nucleosides obtained through a regioselective enzymatic alcoholysis

Biotechnol Lett. 2007 Aug;29(8):1217-20. doi: 10.1007/s10529-007-9374-x. Epub 2007 May 25.

Abstract

Two new compounds, 2',3'-di-O-ethoxycarbonyluridine and 2',3'-di-O-ethoxycarbonylinosine, were obtained through a Candida antarctica lipase B catalysed regioselective ethanolysis of the corresponding trialcoxycarbonylated nucleosides with benzyl alcohol in 1,4-dioxane at 30 degrees C.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / chemistry*
  • Candida / enzymology*
  • Catalysis
  • Computational Biology / methods*
  • Dioxanes / chemistry
  • Enzymes / chemistry
  • Fungal Proteins
  • Lipase / chemistry
  • Models, Chemical
  • Nucleosides / chemistry*
  • Stereoisomerism
  • Substrate Specificity
  • Temperature

Substances

  • Alcohols
  • Dioxanes
  • Enzymes
  • Fungal Proteins
  • Nucleosides
  • Lipase
  • lipase B, Candida antarctica
  • 1,4-dioxane