We report a very rare case of intraosseous ganglion cyst of the capitate in a 54-year-old female who complained of a painful right wrist mass for 1 year. Computed tomography study showed an expansile osteolytic lesion with sclerotic margin and thinning of the cortex. Combined soft tissue ganglion cyst was also noted at operation and confirmed by pathologic study. The case was treated by a new method of autogenous bone marrow and fibrin clot graft after intralesional curettage. After a 2-year follow-up, the capitate revealed complete bony union and the symptoms were relieved with good functional results.