Abstract
Z-ajoene is a garlic-derived compound with known anti-tumour properties. This report argues in favour of pro-apoptotic and cell cycle blockage activities of Z-ajoene on various cell lines involving activation of the p53-family gene products, p53, p63 and p73, at indicated doses. According to its known anti-proteasome activity, Z-ajoene induced a downregulation of MHC-class I expression at the surface of treated cells but did not impair their recognition by CD8+ T cells. We further demonstrated a new activity of Z-ajoene against human cytomegalovirus spreading in vitro that was mediated by an increased number of apoptotic cells after infection. Altogether our data point at the ubiquitous efficiency of Z-ajoene as a new compound to fight against cancers of various origins including those that put up viruses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects*
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CD8-Positive T-Lymphocytes / drug effects
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CD8-Positive T-Lymphocytes / immunology
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Cell Line, Tumor
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Cytomegalovirus / drug effects*
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Cytomegalovirus / physiology
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Disulfides / pharmacology*
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Fibroblasts / drug effects
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Fibroblasts / virology
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Genes, MHC Class I / physiology
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HLA-A2 Antigen / metabolism
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Humans
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Proteasome Endopeptidase Complex / metabolism
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RNA, Messenger / metabolism
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Sulfoxides
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Trans-Activators / genetics
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Trans-Activators / metabolism
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Transcription Factors
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Tumor Protein p73
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / metabolism
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Tumor Suppressor Proteins / genetics
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Tumor Suppressor Proteins / metabolism
Substances
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Antineoplastic Agents
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DNA-Binding Proteins
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Disulfides
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HLA-A2 Antigen
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Nuclear Proteins
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RNA, Messenger
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Sulfoxides
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TP63 protein, human
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TP73 protein, human
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Trans-Activators
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Transcription Factors
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Tumor Protein p73
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Tumor Suppressor Protein p53
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Tumor Suppressor Proteins
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ajoene
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Proteasome Endopeptidase Complex