Composting processes are normally complicated with a variety of uncertainties arising from incomplete or imprecise information obtained in real-world systems. Previously, there has been a lack of studies that focused on developing effective approaches to incorporate such uncertainties within composting process models. To fill this gap, a fuzzy composting process model (FCPM) for simulating composting process under uncertainty was developed. This model was mainly based on integration of a fractional fuzzy vertex method and a comprehensive composting model. Degrees of influence by projected uncertain factors were also examined. Two scenarios were investigated in applying the FCPM method. In the first scenario, model simulation under deterministic conditions was conducted. A pilot-scale experiment was provided for verifications. The result indicated that the proposed composting model could provide an excellent vehicle for demonstrating the complex interactions that occurred in the composting process. In the second scenario, application of the proposed FCPM was conducted under uncertainties. Six input parameters were considered to be of uncertain features that were reflected as fuzzy membership functions. The results indicated that the uncertainties projected in input parameters will result in significant derivations on system predictions; the proposed FCPM can generate satisfactory system outputs, with less computational efforts being required. Analyses on degree of influence of system inputs were also provided to describe the impacts of uncertainties on system responses. Thus, suitable measures can be adopted either to reduce system uncertainty by well-directed reduction of uncertainties of those high-influencing parameters or to reduce the computational requirement by neglecting those negligible factors.