Abstract
Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1-3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Benzimidazoles / isolation & purification
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Benzimidazoles / pharmacology
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Breast Neoplasms / pathology
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Candida albicans / drug effects
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Cell Proliferation / drug effects*
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Cyclopentanes / isolation & purification
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Cyclopentanes / pharmacology
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Garcinia / chemistry*
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Humans
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Lung Neoplasms / pathology
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Phenols / isolation & purification
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Phenols / pharmacology
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Tumor Cells, Cultured / drug effects
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Xanthones / isolation & purification
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Xanthones / pharmacology
Substances
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2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole
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Antifungal Agents
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Antineoplastic Agents
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Benzimidazoles
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Cyclopentanes
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Phenols
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Xanthones