Clearance of hepatitis C virus in HIV-infected patients with multiple chronic viral hepatitis

J Viral Hepat. 2007 Jun;14(6):392-5. doi: 10.1111/j.1365-2893.2006.00839.x.

Abstract

Viral interferences between hepatitis C (HCV) and hepatitis B (HBV) viruses were investigated in a case-control study conducted in 107 human immunodeficiency virus (HIV)-infected patients with HCV antibodies. Overall, 15 (68%) of 22 hepatitis B surface antigen (HBsAg)-positive patients had negative serum HCV-RNA while it occurred in only nine (10%) of 85 HBsAg-negative counterparts (P = 0.02). After adjusting for age, antiretroviral therapy, plasma HIV-RNA and CD4 counts, being HBsAg-positive was strongly associated with having negative serum HCV-RNA (odds ratio: 23; 95% confidence interval: 6-59; P < 0.001). Thus, HBV may favour the elimination of HCV in HIV-infected patients, which may influence liver disease and therapeutic decisions.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alanine Transaminase / blood
  • Anti-Retroviral Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active
  • CD4 Lymphocyte Count
  • Case-Control Studies
  • Female
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • HIV Infections / immunology
  • HIV* / genetics
  • HIV* / isolation & purification
  • Hepacivirus / genetics
  • Hepacivirus / isolation & purification
  • Hepacivirus / physiology*
  • Hepatitis B Surface Antigens / blood
  • Hepatitis B virus / physiology*
  • Hepatitis B, Chronic / blood
  • Hepatitis B, Chronic / complications*
  • Hepatitis C Antibodies / blood
  • Hepatitis C, Chronic / blood
  • Hepatitis C, Chronic / complications
  • Hepatitis C, Chronic / virology*
  • Humans
  • Male
  • RNA, Viral / blood
  • Retrospective Studies
  • Viral Interference*

Substances

  • Anti-Retroviral Agents
  • Hepatitis B Surface Antigens
  • Hepatitis C Antibodies
  • RNA, Viral
  • Alanine Transaminase