Abstract
Two anthraquinones, zenkequinones A and B were isolated from the stem bark of Stereospermum zenkeri together with known sterequinone-F, p-coumaric acid, sitosterol-3-O-beta-D-glucopyranoside and 3beta-hydroxyolean-12-en-28-O-beta-D-glucopyranoside. Their structures were established by spectroscopic methods. The antimicrobial activity of the isolated compounds was evaluated against six multiresistant strains of pathogens. Zenkequinone B showed the best antibacterial activity (MIC 9.50 microg/ml) against gram-negative Pseudomonas aeruginosa.
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification
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Anthraquinones / pharmacology*
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology*
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Bignoniaceae / chemistry*
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Coumaric Acids / chemistry
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Coumaric Acids / isolation & purification
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Coumaric Acids / pharmacology
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Glucosides / chemistry
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Microbial Sensitivity Tests
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Plant Bark / chemistry
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Propionates
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Pseudomonas aeruginosa / drug effects
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Sitosterols / chemistry
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Sitosterols / isolation & purification
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Sitosterols / pharmacology
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
Substances
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3beta-hydroxyolean-12-en-28-O-beta-D-glucopyranoside
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Anthraquinones
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Anti-Infective Agents
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Coumaric Acids
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Glucosides
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Propionates
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Sitosterols
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Triterpenes
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sitosterol-3-O-glucopyranoside
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sterequinone F
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zenkequinone A
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zenkequinone B
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p-coumaric acid