We describe the therapeutic indications for central nervous system cavernomas based on three criteria: 1) Single and multiple lesions: indications are the same, considering that in multiple lesions, one location can be symptomatic; 2) locations: indications are easy to define for exophytic cavernomas close to the hemisphere, brain stem or cerebellum pial surface, or to the ventricular ependyma; 3) symptomatic and non symptomatic presentations: usually, symptomatic forms require surgery except deep lesions located in functional zones distant from the ependyma or the pia matter, unless life prognosis is compromised. Treatment of a symptomatic forms remains debatable, opinion being divided between therapeutic abstention and surgery (in case of cavernomas close to the pia matter or the ependyma). Scientific data strongly support surgical indication for lesions presenting with epilepsy specially when drug-resistant; 4) natural history: prevention against hemorrhage is an argument in favor of surgery for the lesions located in non functional zones or where the risk of bleeding is higher, especially in the brain stem. Discrepancy in the risk of bleeding reported in the literature tends to temper this attitude. Radiosurgery is exceptionally reserved for technically inoperable cavernomas. Partial protection for two years can be expected. Epileptic seizures decrease but few prospective randomised studies are available. The rate of complication appears to be higher than in other affections.