Diagnosis of a critical respiratory illness caused by human metapneumovirus by use of a pan-virus microarray

J Clin Microbiol. 2007 Jul;45(7):2340-3. doi: 10.1128/JCM.00364-07. Epub 2007 May 9.

Abstract

A pan-virus DNA microarray (Virochip) was used to detect a human metapneumovirus (hMPV) strain associated with a critical respiratory tract infection in an elderly adult with chronic lymphocytic leukemia. This infection had previously eluded diagnosis despite extensive microbiological testing for possible etiologic agents. The patient's hMPV strain did not grow in viral culture, and only one of five specific reverse transcription-PCR assays for hMPV was positive.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anti-Infective Agents / therapeutic use
  • Humans
  • Male
  • Metapneumovirus / genetics
  • Metapneumovirus / isolation & purification*
  • Molecular Sequence Data
  • Oligonucleotide Array Sequence Analysis / methods*
  • Paramyxoviridae Infections / diagnosis
  • Paramyxoviridae Infections / virology*
  • Phylogeny
  • Respiratory Tract Infections / drug therapy
  • Respiratory Tract Infections / virology*

Substances

  • Anti-Infective Agents

Associated data

  • GENBANK/EF088284
  • GENBANK/EF088285