Importance of interaction between C1 domain and lipids in protein kinase C alpha activation: hydrophobic side chain direction in isobenzofuranone ligands controls enzyme activation level

ChemMedChem. 2007 Jul;2(7):1006-9. doi: 10.1002/cmdc.200700080.

Authors

Go Hirai¹, Tadashi Shimizu, Toru Watanabe, Yosuke Ogoshi, Megumi Ohkubo, Mikiko Sodeoka

Affiliation

¹ Synthetic Organic Chemistry Laboratory, RIKEN, 2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan.

PMID: 17492704
DOI: 10.1002/cmdc.200700080

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Enzyme Activation
Furans / chemistry
Furans / metabolism*
Hydrogen Bonding
Ligands
Models, Molecular
Protein Kinase C-alpha / metabolism*
Structure-Activity Relationship

Substances

Furans
Ligands
Protein Kinase C-alpha