Abstract
Investigation of an organic extract of Schisandra rubriflora led to the isolation of three new highly oxygenated nortriterpenoids, named rubriflorins A-C (1-3), together with six related known compounds (4-9). Their structures were elucidated by spectroscopic evidence. Compounds 1-3 feature the opening of ring A compared with related known nortriterpenoids isolated from the genus Schisandra and showed anti-HIV-1 activities with EC50 values of 10.0, 16.2, and 81.3 microg/mL, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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HIV-1 / drug effects*
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Molecular Structure
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
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Schisandra / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Anti-HIV Agents
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Drugs, Chinese Herbal
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Triterpenes
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rubriflorin A
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rubriflorin B
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rubriflorin C