Doxorubicin pharmacokinetics in lymphoma patients treated with doxorubicin-loaded eythrocytes

Haematologica. 2007 Apr;92(4):570-1. doi: 10.3324/haematol.10770.

Abstract

Doxorubicin-loaded erythrocytes (DLE) were administrated to 15 lymphoma patients. Antibiotic peak concentration in blood decreased by 55%, doxorubicin circulated several times longer, and the area under the concentration-time curve increased 5 times if compared with standard doxorubicin administration. The DLE was well tolerated by patients.

Publication types

  • Letter

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / pharmacokinetics*
  • Antibiotics, Antineoplastic / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bleomycin / administration & dosage
  • Blood Transfusion, Autologous
  • Cyclophosphamide / administration & dosage
  • Dacarbazine / administration & dosage
  • Doxorubicin / administration & dosage
  • Doxorubicin / blood
  • Doxorubicin / pharmacokinetics*
  • Doxorubicin / therapeutic use
  • Drug Carriers
  • Erythrocyte Transfusion
  • Erythrocytes
  • Female
  • Humans
  • Lymphoma / blood
  • Lymphoma / drug therapy*
  • Male
  • Middle Aged
  • Prednisone / administration & dosage
  • Vinblastine / administration & dosage
  • Vincristine / administration & dosage

Substances

  • Antibiotics, Antineoplastic
  • Drug Carriers
  • Bleomycin
  • Vincristine
  • Vinblastine
  • Dacarbazine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • ABVD protocol
  • CHOP protocol