Abstract
Doxorubicin-loaded erythrocytes (DLE) were administrated to 15 lymphoma patients. Antibiotic peak concentration in blood decreased by 55%, doxorubicin circulated several times longer, and the area under the concentration-time curve increased 5 times if compared with standard doxorubicin administration. The DLE was well tolerated by patients.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Antibiotics, Antineoplastic / administration & dosage
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Antibiotics, Antineoplastic / pharmacokinetics*
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Antibiotics, Antineoplastic / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bleomycin / administration & dosage
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Blood Transfusion, Autologous
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Cyclophosphamide / administration & dosage
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Dacarbazine / administration & dosage
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Doxorubicin / administration & dosage
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Doxorubicin / blood
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Doxorubicin / pharmacokinetics*
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Doxorubicin / therapeutic use
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Drug Carriers
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Erythrocyte Transfusion
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Erythrocytes
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Female
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Humans
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Lymphoma / blood
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Lymphoma / drug therapy*
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Male
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Middle Aged
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Prednisone / administration & dosage
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Vinblastine / administration & dosage
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Vincristine / administration & dosage
Substances
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Antibiotics, Antineoplastic
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Drug Carriers
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Bleomycin
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Vincristine
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Vinblastine
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Dacarbazine
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Doxorubicin
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Cyclophosphamide
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Prednisone
Supplementary concepts
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ABVD protocol
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CHOP protocol