Abstract
This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O(6)-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.
Publication types
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Historical Article
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Alkylating Agents / toxicity
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Animals
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Cloning, Molecular
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DNA Modification Methylases / genetics
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DNA Modification Methylases / history
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DNA Repair
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DNA Repair Enzymes / genetics
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DNA Repair Enzymes / history
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Escherichia coli / drug effects
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Escherichia coli / genetics
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Escherichia coli / metabolism
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Guanine / analogs & derivatives
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Guanine / chemistry
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History, 20th Century
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History, 21st Century
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Humans
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Methylnitronitrosoguanidine / toxicity
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Mutation
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O(6)-Methylguanine-DNA Methyltransferase* / genetics
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O(6)-Methylguanine-DNA Methyltransferase* / history
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Tumor Suppressor Proteins / genetics
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Tumor Suppressor Proteins / history
Substances
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Alkylating Agents
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Tumor Suppressor Proteins
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Methylnitronitrosoguanidine
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Guanine
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O-(6)-methylguanine
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DNA Modification Methylases
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MGMT protein, human
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O(6)-Methylguanine-DNA Methyltransferase
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DNA Repair Enzymes