Preclinical evaluation by flat-panel detector-based volumetric CT versus MRI of intervertebral spacers implanted in a porcine model

Spine J. 2007 May-Jun;7(3):360-7. doi: 10.1016/j.spinee.2006.03.017. Epub 2006 Nov 20.

Abstract

Background context: Image quality and implant detectability by conventional imaging methods are suboptimal for perioperative spinal diagnostics, primarily limited by implant-related artifacts.

Purpose: To evaluate the imaging quality of various intervertebral spacers examined by flat-panel detector-based volumetric computed tomography (FD-VCT) versus magnetic resonance imaging (MRI).

Study design/setting: A preclinical comparative study on an experimental porcine model. The study was performed at a university research facility.

Methods: Three different intervertebral spacer types (titanium, carbon fiber-reinforced polymer, cobalt-chrome-molybdenum) were implanted in a cadaveric porcine spine and then examined by MRI using T1-weighted spin echo (T1w-SE) and turbo spin echo (T1w-TSE) sequences. Comparative imaging was performed with an experimentally approved FD-VCT prototype featuring two-dimensional and three-dimensional imaging and high isotropic spatial resolution. Data analysis focused on spacer shape, implant positioning, and implant-bone interface.

Results: Compared with MRI, and despite the use of T1w-SE and T1w-TSE sequences, the image quality and detectability of all target characteristics were better with FD-VCT absent the usual artifacts. Using its option for implant-specific imaging, the experimental FD-VCT imager allowed reliable determination of additional variables such as dimension and volume.

Conclusions: This experimental study provides initial evidence that FD-VCT produces excellently sharp, high-accuracy, artifact-free imaging quality that is superior to MRI in distinguishing key characteristics of intervertebral implants in a preclinical setting.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Magnetic Resonance Imaging*
  • Orthopedic Fixation Devices*
  • Spine / diagnostic imaging*
  • Spine / surgery*
  • Swine
  • Tomography, X-Ray Computed*