Abstract
Two ellagic acid glycosides were isolated by bioassay-guided fractionation from the antimicrobial ethyl acetate fraction of the ethanol extract from Gleditsia sinensis spines, and identified as 3-O-methylellagic acid-4'-(5''-acetyl)-alpha-L-arabinofuranoside (1) and 3-O-methylellagic acid-4'-O-alpha-L-rhamnopyranoside (2). Both compounds were isolated from this plant species for the first time, and 1 is a new compound. The two compounds showed significant antifungal activity against the spore germination of rice blast fungus Magnaporthe grisea, with an IC(50) value of 13.56 microg mL(-1) for 1 and 16.14 microg mL(-1) for 2.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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China
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology
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Ellagic Acid / analogs & derivatives*
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Ellagic Acid / chemistry
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Ellagic Acid / isolation & purification
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Ellagic Acid / pharmacology
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Gleditsia / chemistry*
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology*
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Inhibitory Concentration 50
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Magnaporthe / drug effects*
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Magnaporthe / growth & development
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Magnetic Resonance Spectroscopy
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Spectrometry, Mass, Electrospray Ionization
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Spectroscopy, Fourier Transform Infrared
Substances
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Antifungal Agents
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Drugs, Chinese Herbal
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Glycosides
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Ellagic Acid