[Identification of the origin of marker chromosome by comparative genomic hybridization]

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Apr;32(2):264-7.
[Article in Chinese]

Abstract

Objective: To identify the origin of the marker chromosome in a patient with chromosome aberration, and to provide the precise genetic diagnosis.

Methods: Comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH) were performed to detect the known small marker chromosome in this patient.

Results: The small marker chromosome originated from chromosome 13 pter->q12.

Conclusion: CGH and FISH can be used to detect the small marker chromosome, which is convenient and quick in detecting the origin of small marker chromosome.

Publication types

  • Case Reports
  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Aberrations*
  • Chromosome Deletion
  • Chromosomes, Human, Pair 13 / genetics*
  • Female
  • Genome, Human
  • Humans
  • In Situ Hybridization, Fluorescence / methods*
  • Karyotyping
  • Nucleic Acid Hybridization / methods*