2-Chloro-6-(2-furyl)-9-(4-methoxybenzyl)-9H-purine

Morten Braendvang; Lise Lotte Gundersen

doi:10.1107/S0108270107011596

2-Chloro-6-(2-furyl)-9-(4-methoxybenzyl)-9H-purine

Acta Crystallogr C. 2007 May;63(Pt 5):o274-6. doi: 10.1107/S0108270107011596. Epub 2007 Apr 14.

Authors

Morten Braendvang¹, Lise Lotte Gundersen

Affiliation

¹ Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N-0315 Oslo, Norway. morten.brandvang@kjemi.uio.no

PMID: 17478910
DOI: 10.1107/S0108270107011596

Abstract

The title compound, C(17)H(13)ClN(4)O(2), displays profound and selective activity against Mycobacterium tuberculosis. In the crystal structure, there are two independent molecules in the asymmetric unit. Intermolecular hydrogen bonding between a CH group of the purine ring and the O atom of the furan ring, and also pi-pi stacking in another direction, builds the three-dimensional network.

MeSH terms

Antitubercular Agents / chemistry*
Antitubercular Agents / pharmacology
Crystallography, X-Ray
Hydrogen Bonding
Models, Molecular
Molecular Conformation
Molecular Structure
Mycobacterium tuberculosis / drug effects
Purines / chemistry*
Purines / pharmacology

Substances

2-chloro-6-(2-furyl)-9-(4-methoxyphenylmethyl)-9H-purine
Antitubercular Agents
Purines