Multilevel regulation of growth rate in yeast revealed using systems biology

J Biol. 2007;6(2):3. doi: 10.1186/jbiol56.

Abstract

The effect of changing growth rates on the transcriptome, proteome and metabolome has been systematically studied. Measurements made under varying nutrient conditions, corresponding to biochemical pathways that correlate primarily with growth rate, reveal a central role for mitochondrial metabolism and the TOR (target of rapamycin) signaling pathway.

Publication types

  • Review

MeSH terms

  • Gene Expression Profiling
  • Gene Expression Regulation, Fungal / physiology*
  • Mitochondria / genetics
  • Mitochondria / metabolism
  • Protein Kinases / genetics
  • Protein Kinases / metabolism
  • Proteome
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development*
  • Signal Transduction
  • Systems Biology / methods*
  • TOR Serine-Threonine Kinases

Substances

  • Proteome
  • Protein Kinases
  • TOR Serine-Threonine Kinases