Abstract
Mononuclear complexes of Cu(II), Ni(II), and Mn(II) with a new Schiff base ligand derived from indoline-2,3-dione and 2-hydroxybenzohydrazide, [Cu(II)(L)(2)], [Ni(II)(L)(2)], and [Mn(II)L.(AcO).2C(2)H(5)OH] [HL=(Z)-2-hydroxy-N'-(2-oxoindolin-3-ylidene)benzohydrazide], have been prepared. The complexes have been structurally characterized by X-ray crystallography. Among the three complexes, the Cu(II) complex had the novel highest antitumor activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Chemistry, Pharmaceutical / methods*
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Copper / chemistry*
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Crystallography, X-Ray
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Drug Design
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Humans
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Hydrazines / chemistry*
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Inhibitory Concentration 50
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K562 Cells
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Ligands
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Manganese / chemistry*
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Models, Chemical
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Models, Molecular
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Nickel / chemistry*
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Spectrophotometry, Ultraviolet
Substances
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Antineoplastic Agents
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Hydrazines
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Ligands
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Manganese
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Copper
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Nickel