The solution conformation of C-glycosyl analogues of the sialyl-Tn antigen

Víctor García-Aparicio; Adeline Malapelle; Zouleika Abdallah; Gilles Doisneau; José Ignacio Santos; Juan Luis Asensio; Francisco Javier Cañada; Jean Marie Beau; Jesús Jiménez-Barbero

doi:10.1016/j.carres.2007.03.021

The solution conformation of C-glycosyl analogues of the sialyl-Tn antigen

Carbohydr Res. 2007 Sep 3;342(12-13):1974-82. doi: 10.1016/j.carres.2007.03.021. Epub 2007 Mar 28.

Authors

Víctor García-Aparicio¹, Adeline Malapelle, Zouleika Abdallah, Gilles Doisneau, José Ignacio Santos, Juan Luis Asensio, Francisco Javier Cañada, Jean Marie Beau, Jesús Jiménez-Barbero

Affiliation

¹ Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain.

PMID: 17466287
DOI: 10.1016/j.carres.2007.03.021

Abstract

The conformational behavior of two C-glycosyl analogues of the sialyl-Tn antigen has been determined by a combination of NMR methods and molecular mechanics calculations. Both compounds show a major solution conformation that is drastically different from the major one of the natural compound.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Tumor-Associated, Carbohydrate / chemistry*
Carbohydrate Conformation
Disaccharides / chemistry
Glycosylation
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Conformation
N-Acetylneuraminic Acid / chemistry*
Solutions

Substances

Antigens, Tumor-Associated, Carbohydrate
Disaccharides
Solutions
Tn antigen
N-Acetylneuraminic Acid