Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1

MeSH terms

• Amyloid Precursor Protein Secretases / antagonists & inhibitors*
• Amyloid Precursor Protein Secretases / chemistry
• Aspartic Acid Endopeptidases / antagonists & inhibitors*
• Aspartic Acid Endopeptidases / chemistry
• Binding Sites
• Crystallography, X-Ray
• Hydrogen Bonding
• Imidazolidines / chemical synthesis*
• Imidazolidines / chemistry
• Imidazolidines / pharmacology*
• Mass Spectrometry
• Models, Molecular
• Protease Inhibitors / chemical synthesis*
• Protease Inhibitors / chemistry
• Protease Inhibitors / pharmacology*