Treatment failure in a case of extensively drug-resistant tuberculosis associated with selection of a GyrB mutant causing fluoroquinolone resistance

Eur J Clin Microbiol Infect Dis. 2007 Jun;26(6):423-5. doi: 10.1007/s10096-007-0298-0.

Authors

N Veziris¹, C Martin, F Brossier, F Bonnaud, F Denis, A Aubry

Affiliation

¹ Laboratoire de Bactériologie, Faculté de Médecine Pierre et Marie Curie, Université Paris 6 et Centre National de Référence de la Résistance des Mycobactéries et de la Résistance aux Antituberculeux, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

PMID: 17458568
DOI: 10.1007/s10096-007-0298-0

No abstract available

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / therapeutic use*
Bacterial Proteins / genetics
DNA Gyrase / genetics*
Drug Resistance, Multiple, Bacterial*
Fatal Outcome
Fluoroquinolones / therapeutic use*
Humans
Lung / diagnostic imaging
Male
Middle Aged
Mutation
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / genetics
Mycobacterium tuberculosis / isolation & purification
Radiography
Treatment Failure
Tuberculosis, Multidrug-Resistant / drug therapy*
Tuberculosis, Multidrug-Resistant / microbiology*

Substances

Anti-Bacterial Agents
Bacterial Proteins
Fluoroquinolones
DNA Gyrase