Abstract
The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N'-diacetic acid (EDDA) as coligands. The effects of different spacers between thymidine analog with HYNIC on radiochemical yield were also studied.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chelating Agents / chemistry
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Edetic Acid / analogs & derivatives
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Edetic Acid / chemistry
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Glycine / analogs & derivatives
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Glycine / chemistry
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Isotope Labeling
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Ligands
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Magnetic Resonance Imaging / methods*
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Models, Chemical
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Neoplasms / diagnosis*
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Radiopharmaceuticals* / chemical synthesis
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Technetium / chemistry*
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Thymidine* / analogs & derivatives
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Thymidine* / chemical synthesis
Substances
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Chelating Agents
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Ligands
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Radiopharmaceuticals
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EDDA
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Technetium
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Edetic Acid
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Glycine
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Thymidine
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tricine