Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3440-4. doi: 10.1016/j.bmcl.2007.03.086. Epub 2007 Mar 30.

Abstract

The technetium-99m-labeling and synthesis of a series of thymidine analogs were studied. The target molecules were obtained by using 6-hydrazinopyridine-3-carboxylic acid (HYNIC) as a bifunctional coupling agent and using N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine (tricine) and ethylenediamine-N,N'-diacetic acid (EDDA) as coligands. The effects of different spacers between thymidine analog with HYNIC on radiochemical yield were also studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chelating Agents / chemistry
  • Edetic Acid / analogs & derivatives
  • Edetic Acid / chemistry
  • Glycine / analogs & derivatives
  • Glycine / chemistry
  • Isotope Labeling
  • Ligands
  • Magnetic Resonance Imaging / methods*
  • Models, Chemical
  • Neoplasms / diagnosis*
  • Radiopharmaceuticals* / chemical synthesis
  • Technetium / chemistry*
  • Thymidine* / analogs & derivatives
  • Thymidine* / chemical synthesis

Substances

  • Chelating Agents
  • Ligands
  • Radiopharmaceuticals
  • EDDA
  • Technetium
  • Edetic Acid
  • Glycine
  • Thymidine
  • tricine