Two new antifungal alkaloids produced by Streptoverticillium morookaense

J Antibiot (Tokyo). 2007 Mar;60(3):179-83. doi: 10.1038/ja.2007.19.

Abstract

A new carbazole alkaloid, streptoverticillin, and a new 2-azetidinone, streptoverticillinone, along with three known cyclodipeptides were isolated from the mycelial solid culture of Streptoverticillium morookaense. Their structures were elucidated by analysis of 1D and 2D NMR, mass spectra and optical rotation data. Two new compounds exhibited antifungal activity against Peronophythora litchii.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / biosynthesis*
  • Alkaloids / chemistry
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / metabolism*
  • Antifungal Agents / pharmacology*
  • Carbazoles / chemistry
  • Carbazoles / isolation & purification
  • Carbazoles / pharmacology
  • Fungi / drug effects*
  • Litchi / microbiology
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry / methods
  • Microbial Sensitivity Tests
  • Optical Rotation
  • Plant Diseases / microbiology
  • Pyrrolidines / chemistry
  • Pyrrolidines / isolation & purification
  • Pyrrolidines / pharmacology
  • Streptomyces / growth & development
  • Streptomyces / metabolism*

Substances

  • Alkaloids
  • Antifungal Agents
  • Carbazoles
  • Pyrrolidines
  • streptoverticillin
  • streptoverticillinone