We investigated the relationships between serum albumin and ferritin levels in chronic hemodialysis patients with or without major depression. During a 1-year period, a total of 107 chronic hemodialysis patients were recruited. The diagnosis of major depression in patients was made by one psychiatrist. The data showed that patients with major depression (n=15) had significantly lower albumin and higher ferritin levels than patients without major depression (n=92). Chronic hemodialysis patients with major depression might have a more severe inflammation reaction and greater oxidative damage than patients without major depression.