Liver injury induced by a Japanese herbal medicine, sairei-to (TJ-114, Bupleurum and Hoelen Combination, Chai-Ling-Tang) R1

J Gastroenterol Hepatol. 2007 May;22(5):762-3. doi: 10.1111/j.1440-1746.2006.03373.x.

Abstract

The case is reported of a man who showed acute hepatitis with jaundice after he was given a Japanese herbal medicine, sairei-to (TJ-114, Bupleurum and Hoelen Combination, Chai-Ling-Tang). Unusually, the component thought to be responsible for the observed drug-induced liver injury was able to be identified. Lymphocyte migration inhibition testing indicated that the tuber of the perennial herbage Pinellia ternate was the causative agent.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Alanine Transaminase / blood
  • Aspartate Aminotransferases / blood
  • Bilirubin / blood
  • Cell Migration Inhibition
  • Cell Movement / drug effects
  • Chemical and Drug Induced Liver Injury / enzymology
  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / immunology
  • Chemical and Drug Induced Liver Injury / metabolism
  • Drugs, Chinese Herbal / adverse effects*
  • Drugs, Chinese Herbal / chemistry
  • Fertility Agents, Male / adverse effects*
  • Fertility Agents, Male / chemistry
  • Humans
  • Jaundice / chemically induced*
  • Jaundice / enzymology
  • Jaundice / immunology
  • Jaundice / metabolism
  • L-Lactate Dehydrogenase / blood
  • Lymphocytes / drug effects
  • Lymphocytes / immunology
  • Male
  • Pinellia / adverse effects
  • Plant Tubers / adverse effects

Substances

  • Drugs, Chinese Herbal
  • Fertility Agents, Male
  • sairei-to
  • L-Lactate Dehydrogenase
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Bilirubin