Abstract
The case is reported of a man who showed acute hepatitis with jaundice after he was given a Japanese herbal medicine, sairei-to (TJ-114, Bupleurum and Hoelen Combination, Chai-Ling-Tang). Unusually, the component thought to be responsible for the observed drug-induced liver injury was able to be identified. Lymphocyte migration inhibition testing indicated that the tuber of the perennial herbage Pinellia ternate was the causative agent.
MeSH terms
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Acute Disease
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Adult
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Alanine Transaminase / blood
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Aspartate Aminotransferases / blood
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Bilirubin / blood
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Cell Migration Inhibition
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Cell Movement / drug effects
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Chemical and Drug Induced Liver Injury / enzymology
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Chemical and Drug Induced Liver Injury / etiology*
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Chemical and Drug Induced Liver Injury / immunology
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Chemical and Drug Induced Liver Injury / metabolism
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Drugs, Chinese Herbal / adverse effects*
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Drugs, Chinese Herbal / chemistry
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Fertility Agents, Male / adverse effects*
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Fertility Agents, Male / chemistry
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Humans
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Jaundice / chemically induced*
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Jaundice / enzymology
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Jaundice / immunology
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Jaundice / metabolism
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L-Lactate Dehydrogenase / blood
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Lymphocytes / drug effects
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Lymphocytes / immunology
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Male
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Pinellia / adverse effects
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Plant Tubers / adverse effects
Substances
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Drugs, Chinese Herbal
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Fertility Agents, Male
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sairei-to
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L-Lactate Dehydrogenase
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Aspartate Aminotransferases
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Alanine Transaminase
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Bilirubin