Abstract
A new electrophilic difluoromethylating reagent has been developed. The S-(difluoromethyl)diarylsulfonium tetrafluoroborate has been shown to be effective for the introduction of an electrophilic difluoromethyl group into the following nucleophiles: sulfonic acids, tertiary amines, imidazole derivatives, and phosphines. The reagent failed to transfer the difluoromethyl group to phenols, carbon nucleophiles, and primary and secondary amines.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amines / chemistry
-
Boric Acids / chemistry
-
Electrons*
-
Fluorine / chemistry*
-
Imidazoles / chemistry
-
Indicators and Reagents / chemistry
-
Methylation
-
Molecular Structure
-
Nitroimidazoles / chemistry
-
Phosphines / chemistry
-
Sulfones / chemistry
-
Sulfonium Compounds / chemical synthesis
-
Sulfonium Compounds / chemistry
Substances
-
Amines
-
Boric Acids
-
Imidazoles
-
Indicators and Reagents
-
Nitroimidazoles
-
Phosphines
-
Sulfones
-
Sulfonium Compounds
-
sulfonidazole
-
Fluorine
-
phosphine
-
boric acid