Analysis of vaccine's schedules using models

Cell Immunol. 2006 Dec;244(2):137-40. doi: 10.1016/j.cellimm.2007.03.002. Epub 2007 Apr 17.

Abstract

We present a further, yet important, step in applying Catania Mouse Model & simulator (SimTriplex) of immune system response to vaccination. In particular we show that, as immune response can induce toxicity, one can calibrate the vaccine administrations in such a way to avoid toxicity effects, keeping immunoprevention from cancer. This result increases the model's potential applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cancer Vaccines / administration & dosage*
  • Cancer Vaccines / immunology*
  • Carcinoma in Situ / immunology*
  • Carcinoma in Situ / prevention & control
  • Computer Simulation
  • Female
  • Immunization Schedule*
  • Mammary Neoplasms, Animal / immunology*
  • Mammary Neoplasms, Animal / prevention & control
  • Mice
  • Mice, Inbred BALB C
  • Mice, Transgenic
  • Models, Immunological*
  • Vaccination / methods*

Substances

  • Cancer Vaccines