A dodecaholmium wheel of [Ho12(L)6(mal)4(AcO)4(H2O)14] (1; mal = malonate) was synthesized by using p-tert-butylsulfonylcalix[4]arene (H4L) as a cluster-forming ligand. The wheel consists of three fragments of mononuclear A3- ([Ho(L)(mal)(H2O)]3-), trinuclear B3- ([Ho(H2O)2(mal)(Ho(L)(AcO))2]3-), and C3+ ([Ho(H2O)2]3+), and an alternate arrangement of these fragments (A(3-)-C(3+)-B(3-)-C(3+)-A(3-)-C(3+)-B(3-)-C(3+)-) results in a wheel structure. The longest and shortest diameters of the core were estimated to be 17.7562(16) and 13.6810(13) A, respectively, and the saddle-shaped molecule possesses a pocketlike cavity inside.