Blimp-1 over Budapest

Nat Immunol. 2007 May;8(5):445-7. doi: 10.1038/ni0507-445.

Abstract

Blimp-1 is a transcription factor that affects the expression of hundreds of genes in lymphocytes. Recent work confirmed its role in the maturation of B cells into immunoglobulin-secreting plasmablasts, as well as in the control of T cell homeostasis and tolerance. What follows is a short history of how Blimp-1 was discovered.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / metabolism
  • Cell Differentiation / physiology*
  • Gene Expression Regulation
  • Humans
  • Immunoglobulins / metabolism*
  • Positive Regulatory Domain I-Binding Factor 1
  • Repressor Proteins / metabolism
  • Repressor Proteins / physiology*
  • Transcription Factors / metabolism*
  • Transcription Factors / physiology

Substances

  • Immunoglobulins
  • Repressor Proteins
  • Transcription Factors
  • PRDM1 protein, human
  • Positive Regulatory Domain I-Binding Factor 1