Abstract
Blimp-1 is a transcription factor that affects the expression of hundreds of genes in lymphocytes. Recent work confirmed its role in the maturation of B cells into immunoglobulin-secreting plasmablasts, as well as in the control of T cell homeostasis and tolerance. What follows is a short history of how Blimp-1 was discovered.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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B-Lymphocytes / immunology*
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B-Lymphocytes / metabolism
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Cell Differentiation / physiology*
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Gene Expression Regulation
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Humans
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Immunoglobulins / metabolism*
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Positive Regulatory Domain I-Binding Factor 1
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Repressor Proteins / metabolism
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Repressor Proteins / physiology*
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Transcription Factors / metabolism*
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Transcription Factors / physiology
Substances
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Immunoglobulins
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Repressor Proteins
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Transcription Factors
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PRDM1 protein, human
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Positive Regulatory Domain I-Binding Factor 1