In this research we present the results of the liver histopathological examinations after the administration of the Piroxicam (Pirox) and its complex combinations with metal bio-ions Cu (II), Co (II), Zn (II) to rats (White Wistar, 150-180 gr.). The results of the histological investigations are presented separately for each compound revealing the modifications after 24 hours and after 7 days. The hepatic lesions are noted in the case of Zn-Pirox after 24 hours and after 7 days, as well. The complexes Cu-Pirox and Co-Pirox don't produce hepatic modifications either after 24 hours or after 7 days according to our histological investigations.