[New biological active derivatives of indomethacin and acetylsalicylic acid. Synthesis, physico-chemical characterisation and structure validation]

Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):1027-30.
[Article in Romanian]

Abstract

It is well known that niflumic acid glycinamide has a good antiinflammatory action useful in gum inflammatory diseases. The objective of this study was to obtain new glycinamides of acetylsalicylic acid and indomethacin, which could have a better antiinflammatory action than niflumic acid glycinamide. The study presents the synthesis, physico-chemical characterisation and structure validation of these glycinamides.

Publication types

  • English Abstract

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry*
  • Aspirin / chemistry*
  • Glycine / analogs & derivatives*
  • Glycine / chemical synthesis
  • Glycine / chemistry
  • Humans
  • Indomethacin / chemistry*
  • Inflammation / drug therapy

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • glycine amide
  • Aspirin
  • Glycine
  • Indomethacin