Neurocognitive indices of executive hypercontrol in obsessive-compulsive disorder

Acta Psychiatr Scand. 2007 May;115(5):380-7. doi: 10.1111/j.1600-0447.2006.00911.x.

Abstract

Objective: Cognitive impairment, more often involving memory and/or executive functions, has been reported in obsessive-compulsive (OC) patients. The present study aimed at: i) replicating, in an independent sample, previous findings by our group showing neurocognitive slowness limited to executive tasks; ii) assessing the influence of deficit in general cognitive abilities on executive dysfunction.

Method: A comprehensive neuropsychological battery was administered to 30 drug-free OC patients and 30 healthy controls.

Results: Obsessive-compulsive patients performed worse on visuospatial tests, were slower on executive tasks, and performed worse on the Wisconsin Card Sorting Test. After covarying for Wechsler Adult Intelligence Scale-Revised performance Intellectual Quotient, a lesser degree of executive dysfunction was observed.

Conclusion: Obsessive-compulsive patients exhibit an impairment of executive functions, especially when tasks also require visuospatial abilities. The impairment might reflect a hyperactivity of the executive control.

MeSH terms

  • Adult
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / psychology
  • Female
  • Humans
  • Internal-External Control*
  • Male
  • Mental Recall
  • Neuropsychological Tests / statistics & numerical data*
  • Obsessive-Compulsive Disorder / diagnosis*
  • Obsessive-Compulsive Disorder / psychology
  • Problem Solving*
  • Psychometrics
  • Reaction Time
  • Reference Values