Artemisinin, promising lead natural product for various drug developments

Mini Rev Med Chem. 2007 Apr;7(4):411-22. doi: 10.2174/138955707780363837.

Abstract

Artemisinin and its synthetic derivatives are widely used for antimalarial agents in the world. Moreover, they are discovered to additionally use as anticancer, antiangiogenesis, antiviral, immunosuppressive, and antifungal agents. Recent research results supported that it is a very promising field in drug discovery. In this review, it will discuss the structural and biological features of artemisinin and its derivatives that have published since 2003 except antimalarial, and show that they are useful lead compounds for novel drug discovery.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / chemistry
  • Angiogenesis Inhibitors / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Antimalarials / chemistry
  • Antimalarials / pharmacology*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Artemisinins / chemistry
  • Artemisinins / pharmacology*
  • Cell Line
  • Drug Design*
  • Humans
  • Immunosuppressive Agents / chemistry
  • Immunosuppressive Agents / pharmacology
  • Lactones / chemistry
  • Lactones / pharmacology*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / pharmacology*

Substances

  • Angiogenesis Inhibitors
  • Antifungal Agents
  • Antimalarials
  • Antiviral Agents
  • Artemisinins
  • Immunosuppressive Agents
  • Lactones
  • Sesquiterpenes
  • artemisin