Statistical tools for synthesizing lists of differentially expressed features in related experiments

Genome Biol. 2007;8(4):R54. doi: 10.1186/gb-2007-8-4-r54.

Abstract

We propose a novel approach for finding a list of features that are commonly perturbed in two or more experiments, quantifying the evidence of dependence between the experiments by a ratio. We present a Bayesian analysis of this ratio, which leads us to suggest two rules for choosing a cut-off on the ranked list of p values. We evaluate and compare the performance of these statistical tools in a simulation study, and show their usefulness on two real datasets.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Feed
  • Animals
  • Bayes Theorem
  • Computer Simulation
  • Data Interpretation, Statistical
  • Dietary Fats / metabolism
  • Gene Expression Profiling*
  • Lung / metabolism
  • Lung Injury
  • Mice
  • Models, Statistical*
  • Oligonucleotide Array Sequence Analysis*
  • Pulmonary Ventilation
  • Rats
  • Ventilators, Mechanical / adverse effects

Substances

  • Dietary Fats