Abstract
The pyrrole derivatives la, b and 2a, b were used as precursors for the preparation of N-substituted pyrrole derivatives 3a, b-9a, b and pyrrolo[2,3-d]pyrimidines 13-16. Also, all the newly prepared products were tested for anti-inflammatory activity as analogues to fenamates, and some of them revealed moderate anti-inflammatory activity compared to the standard drug indomethacin.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Indomethacin / pharmacology
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Models, Molecular
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Molecular Structure
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Pyrimidines / chemistry
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Pyrimidines / isolation & purification
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Pyrimidines / pharmacology
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Pyrroles / chemistry
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Pyrroles / isolation & purification
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Pyrroles / pharmacology
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Rats
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Pyrimidines
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Pyrroles
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Indomethacin