Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2

Arch Pharm Res. 2007 Mar;30(3):270-4. doi: 10.1007/BF02977605.

Abstract

Bioassay-guided fractionation of the EtOAc extract from the fermentation broth of a marine-derived actinomycete Z(2)039-2 led to the isolation of two known indolocarbazole alkaloids, K252c (1) and arcyriaflavin A (2). 1 and 2 exhibited moderate cytotoxic activities against the K562 cell line, and induced apoptotic activities at 10 and 100 microM, respectively. This is the first report on the significant apoptosis inducing effect of indolocarbazole alkaloids against K562 cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinobacteria / metabolism*
  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Apoptosis / drug effects*
  • Carbazoles / chemistry
  • Carbazoles / isolation & purification*
  • Carbazoles / pharmacology
  • Humans
  • Indoles / chemistry
  • Indoles / isolation & purification
  • Indoles / pharmacology
  • K562 Cells
  • Magnetic Resonance Spectroscopy
  • Water Microbiology

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Carbazoles
  • Indoles