Abstract
SU-8 is an epoxy-novolac resin and a well-established negative photoresist for microfabrication and microengineering. The photopolymerized resist is an extremely highly crosslinked polymer showing outstanding chemical and physical robustness with residual surface epoxy groups amenable for chemical functionalization. In this paper we describe, for the first time, the preparation and surface modification of SU-8 particles shaped as microbars, the attachment of appropriate linkers, and the successful application of these particles to multistep solid-phase synthesis leading to oligonucleotides and peptides attached in an unambiguous manner to the support surface.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Chromatography, High Pressure Liquid / methods
-
Combinatorial Chemistry Techniques / methods*
-
Epoxy Compounds / chemical synthesis*
-
Epoxy Compounds / chemistry
-
Epoxy Resins / chemical synthesis*
-
Epoxy Resins / chemistry
-
Mass Spectrometry / methods
-
Microscopy, Electron, Scanning / methods
-
Molecular Structure
-
Oligonucleotides / analysis
-
Oligonucleotides / chemical synthesis
-
Oligonucleotides / chemistry
-
Particle Size
-
Polymers / chemical synthesis*
-
Polymers / chemistry
-
Sensitivity and Specificity
-
Stereoisomerism
-
Time Factors
Substances
-
Epoxy Compounds
-
Epoxy Resins
-
Oligonucleotides
-
Polymers
-
SU-8 compound