Abstract
Fifteen new withanolides (1-8, 11-17) and two known withanolides, withanolide D (9) and 17alpha-hydroxywithanolide D (10), were isolated from the stems, roots, and leaves of Tubocapsicum anomalum using bioassay-directed fractionation. The structures were determined by spectroscopic and chemical methods, and the absolute configurations were established by CD analysis and by the Mosher ester method. The structure of 1 and 3 were further confirmed by X-ray crystallographic analysis. Compounds 1, 4-6, 8-10, and 13 showed significant cytotoxic activity against Hep G2, Hep 3B, A-549, MDA-MB-231, MCF-7, and MRC-5 cell lines.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic* / chemistry
-
Antineoplastic Agents, Phytogenic* / isolation & purification
-
Antineoplastic Agents, Phytogenic* / pharmacology
-
Crystallography, X-Ray
-
Drug Screening Assays, Antitumor
-
Ergosterol / analogs & derivatives*
-
Ergosterol / chemistry
-
Ergosterol / isolation & purification
-
Ergosterol / pharmacology
-
Humans
-
Molecular Conformation
-
Molecular Structure
-
Plant Leaves / chemistry
-
Plant Roots / chemistry
-
Plant Stems / chemistry
-
Plants, Medicinal / chemistry*
-
Solanaceae / chemistry*
-
Taiwan
-
Withanolides
Substances
-
Antineoplastic Agents, Phytogenic
-
Withanolides
-
withanolide D
-
Ergosterol