Effect of endotoxemia on skin antioxidant enzymes under experimental conditions

A V Ivanova; E V Mikhal'chik; E A Miroshnikova; E V Lukasheva; L G Korkina

doi:10.1007/s10517-006-0379-6

Effect of endotoxemia on skin antioxidant enzymes under experimental conditions

Bull Exp Biol Med. 2006 Oct;142(4):413-5. doi: 10.1007/s10517-006-0379-6.

[Article in English, Russian]

Authors

A V Ivanova¹, E V Mikhal'chik, E A Miroshnikova, E V Lukasheva, L G Korkina

Affiliation

¹ Russian State Medical University; Russian People's Friendship University, Moscow.

PMID: 17415424
DOI: 10.1007/s10517-006-0379-6

Abstract

Intraperitoneal injection of bacterial lipopolysaccharide in a dose of 1 mg/kg was followed by prestimulation of whole blood leukocytes in rats. Activities of peroxide- and lipoperoxide-utilizing antioxidant enzymes glutathione peroxidase, glutathione S-transferase, and catalase increased 1 day after lipopolysaccharide administration, while the content of malonic dialdehyde in the skin remained unchanged.

MeSH terms

Animals
Catalase / metabolism*
Endotoxemia / chemically induced
Endotoxemia / enzymology*
Erythrocytes / drug effects
Erythrocytes / metabolism
Glutathione / metabolism
Glutathione Peroxidase / metabolism*
Glutathione Transferase / metabolism*
Lipopolysaccharides / toxicity
Male
Malondialdehyde / metabolism
Rats
Rats, Wistar
Skin / enzymology*
Superoxide Dismutase / metabolism

Substances

Lipopolysaccharides
Malondialdehyde
Catalase
Glutathione Peroxidase
Superoxide Dismutase
Glutathione Transferase
Glutathione