Induction of cell death by photodynamic therapy with water-soluble lipid-membrane-incorporated [60]fullerene

Atsushi Ikeda; Yuki Doi; Koji Nishiguchi; Keiko Kitamura; Mineo Hashizume; Jun-Ichi Kikuchi; Keiichiro Yogo; Takuya Ogawa; Tatsuo Takeya

doi:10.1039/b701767g

Induction of cell death by photodynamic therapy with water-soluble lipid-membrane-incorporated [60]fullerene

Org Biomol Chem. 2007 Apr 21;5(8):1158-60. doi: 10.1039/b701767g. Epub 2007 Mar 16.

Authors

Atsushi Ikeda¹, Yuki Doi, Koji Nishiguchi, Keiko Kitamura, Mineo Hashizume, Jun-Ichi Kikuchi, Keiichiro Yogo, Takuya Ogawa, Tatsuo Takeya

Affiliation

¹ Graduate School of Materials Science, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan. aikeda@ms.naist.jp

PMID: 17406710
DOI: 10.1039/b701767g

Abstract

Intracellular uptake of a lipid-membrane-incorporated C(60) with a cationic surface into HeLa cells was found to induce cell death under visible light irradiation in high efficiency.

MeSH terms

Apoptosis / drug effects
Cell Death / drug effects
Cell Death / radiation effects
Female
Fullerenes / chemistry
Fullerenes / pharmacokinetics
Fullerenes / pharmacology*
HeLa Cells
Humans
Light*
Liposomes / chemical synthesis
Liposomes / chemistry
Membranes, Artificial*
Molecular Structure
Photochemotherapy / methods*
Solubility
Structure-Activity Relationship
Surface Properties
Uterine Cervical Neoplasms / drug therapy*
Uterine Cervical Neoplasms / metabolism
Water / chemistry

Substances

Fullerenes
Liposomes
Membranes, Artificial
Water
fullerene C60