IL-4 inducibility in NKT cells, naïve CD4+ T cells and TCR-gamma delta T cells

J Biomed Sci. 2007 Jul;14(4):533-8. doi: 10.1007/s11373-007-9167-1. Epub 2007 Apr 3.

Abstract

NKT cells, naïve CD4(+) T cells, and TCR-gammadelta T cells belong to distinct T cell lineages but all express T cell receptors generated through random combinatorial joining of V-(D)-J genes. These distinct lineage T cells also possess the property of promptly activating the IL-4 gene upon T cell receptor stimulation. A comparative accounting of features as they pertain to IL-4 inducibility in these three distinct lineage T cells is provided here.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens / metabolism
  • CD4-Positive T-Lymphocytes / immunology*
  • Cell Differentiation
  • Cell Lineage
  • Humans
  • Interferon-gamma / metabolism
  • Interleukin-4 / biosynthesis*
  • Interleukin-4 / genetics
  • Killer Cells, Natural / immunology
  • Receptors, Antigen, T-Cell, gamma-delta / analysis*
  • T-Lymphocyte Subsets / immunology*
  • Thymus Gland / immunology

Substances

  • Antigens
  • Receptors, Antigen, T-Cell, gamma-delta
  • Interleukin-4
  • Interferon-gamma