Abstract
NKT cells, naïve CD4(+) T cells, and TCR-gammadelta T cells belong to distinct T cell lineages but all express T cell receptors generated through random combinatorial joining of V-(D)-J genes. These distinct lineage T cells also possess the property of promptly activating the IL-4 gene upon T cell receptor stimulation. A comparative accounting of features as they pertain to IL-4 inducibility in these three distinct lineage T cells is provided here.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens / metabolism
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CD4-Positive T-Lymphocytes / immunology*
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Cell Differentiation
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Cell Lineage
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Humans
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Interferon-gamma / metabolism
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Interleukin-4 / biosynthesis*
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Interleukin-4 / genetics
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Killer Cells, Natural / immunology
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Receptors, Antigen, T-Cell, gamma-delta / analysis*
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T-Lymphocyte Subsets / immunology*
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Thymus Gland / immunology
Substances
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Antigens
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Receptors, Antigen, T-Cell, gamma-delta
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Interleukin-4
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Interferon-gamma