Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized progressive joint destruction. Recent studies have revealed an essential role of receptor activator of NF-kappaB ligand (RANKL) in bone destruction in RA, and therapeutics targeting RANKL has been attracting a great deal of attention.
MeSH terms
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Arthritis, Rheumatoid / drug therapy*
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Arthritis, Rheumatoid / etiology*
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Arthritis, Rheumatoid / pathology
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Bone Remodeling
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Bone and Bones / pathology
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Cell Differentiation / genetics
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Drug Design*
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Humans
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Osteoclasts / cytology
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Osteoclasts / physiology
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RANK Ligand / physiology*
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Tumor Necrosis Factor-alpha / physiology
Substances
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RANK Ligand
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Tumor Necrosis Factor-alpha